Article

Lificiguat inhibits the collagen production of hepatic stellate cells independently on sGC activity

2025-08-06

Abstract excerpt

<title>Abstract</title> <p>Background Liver fibrosis is driven by activated hepatic stellate cells (HSCs) that overproduce extracellular matrix, particularly collagen. Lificiguat, a soluble guanylate cyclase (sGC) stimulator, exhibits anti-fibrotic potential, but its mechanism in HSC activation remains unclear. This study aims to investigate the anti-fibrotic effect and mechanisms of lificiguat . Methods human HS...

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Literature Corpus work: 4209bbb3-ea86-56fc-9d4c-6aa5f7d1d40e
DOI: 10.21203/rs.3.rs-7224016/v1

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