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Identification of novel targets for the diagnosis and treatment of liver fibrosis

29 Jun 2015

Abstract excerpt

Liver fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) in the hepatic parenchyma and represents an intrinsic response to chronic injury, maintaining organ integrity when extensive necrosis or apoptosis occurs. Hepatic stellate cells (HSCs) are the major cell type responsible for liver fibrosis. Following liver injury, HSCs become activated and transdifferentiate into...

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PMID: 26135677
DOI: 10.3892/ijmm.2015.2264

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