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Article

Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis.

Scientific reports - 11 May 2017

Su Tung-Hung, Shiau Chung-Wai, Jao Ping, Yang Nian-Jie, Tai Wei-Tien, Liu Chun-Jen, Tseng Tai-Chung, Yang Hung-Chih, Liu Chen-Hua, Huang Kai-Wen, Hu Ting-Chen, Huang Yu-Jen, Wu Yao-Ming, Chen Li-Ju, Chen Pei-Jer, Chen Ding-Shinn, Chen Kuen-Feng, Kao Jia-Horng

Abstract excerpt

This study aimed to investigate the role of src-homology protein tyrosine phosphatase-1 (SHP-1)-signal transducer and activator of transcription 3 (STAT3) pathway in liver fibrogenesis and the anti-fibrotic effect of SHP-1 agonist. The antifibrotic activity of SC-43, a sorafenib derivative with an enhanced SHP-1 activity, was evaluated in two fibrosis mouse models by carbon tetrachloride induction and bile duct...

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Identifiers

PMID: 28496142
DOI: 10.1038/s41598-017-01572-z
PMCID: PMC5431996

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STAT3

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