miRNA-150-5p Promotes Hepatic Stellate Cell Proliferation and Sensitizes Hepatocyte Apoptosis During Liver Fibrosis

Abstract excerpt

Aim: To explore the role of miRNA-150-5p (miR-150-5p) in liver fibrosis. Materials & methods: miRNA expression profiles, CCl4-induced liver fibrosis progression and regression rodent models, quantitative real-time PCR, miR-150-5p mimics and inhibitors, cell proliferation and apoptosis detection, RNA sequencing and bioinformatics analysis were employed. Results: Liver tissue miR-150-5p expression was positively...

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