Direct excitatory synapses between neurons and tumor cells drive brain metastatic seeding of breast cancer and melanoma

Abstract excerpt

Interactions between neurons and cancer cells are found in many malignancies, but their relevance for metastatic organ colonization remain largely unknown. It is also unclear whether any direct synaptic communication between neurons and cancer cells of non-neural tumor types exists, and if so, whether this can support metastasis and thus cancer progression. Here we show that excitatory synapses are formed between...

Topics

Open a Topic to create a Post that cites this publication.

• Axon Guidance and Neuronal Signaling
• Cancer, Stress, Anesthesia, and Immune Response
• Exons
• Melanoma
• Mutation
• Nicotinic Acetylcholine Receptors Study
• Receptor Mechanisms and Signaling
• Receptors, G-Protein-Coupled

Identifiers and source

Literature Corpus work

92403c5f-3a34-57b4-b475-f54515d67dd1

DOI

10.1101/2024.01.08.574608