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GABA Regulates Electrical Activity and Tumor Initiation in Melanoma

9 Aug 2023

Abstract excerpt

Oncogenes can initiate tumors only in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells in the microenvironment can endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation by BRAFV600E. GABA is...

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PMID: 37553760
DOI: 10.1158/2159-8290.cd-23-0389

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