Article
Human breast cancer metastases to the brain display GABAergic properties in the neural niche.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014
Neman Josh, Termini John, Wilczynski Sharon, Vaidehi Nagarajan, Choy Cecilia, Kowolik Claudia M, Li Hubert, Hambrecht Amanda C, Roberts Eugene, Jandial Rahul
Abstract excerpt
Dispersion of tumors throughout the body is a neoplastic process responsible for the vast majority of deaths from cancer. Despite disseminating to distant organs as malignant scouts, most tumor cells fail to remain viable after their arrival. The physiologic microenvironment of the brain must become a tumor-favorable microenvironment for successful metastatic colonization by circulating breast cancer cells....
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