Article

Positive-control Mendelian randomization highlights power constraints in disease-mortality GWAS

2026-06-01

Abstract excerpt

Yang et al. recently published a systematic comparison of genetic effects on disease susceptibility and disease-specific mortality across nine common diseases and seven biobanks, concluding that susceptibility and survival architectures overlap only modestly. This is an important resource, but we argue that the current mortality genome-wide association studies (GWAS) require explicit power calibration before limit...

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Literature Corpus work: 922f84ff-1a6e-5e6f-8bf1-6df36f587174
DOI: 10.64898/2026.05.29.26354472

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