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Article

Life-course obesity and heart failure: a two-sample Mendelian randomization study.

Internal and emergency medicine - 1 Jan 2025

Wang Haili, Min Jie, Zhong Lei, Zhang Jinyu, Ye Lili, Chen Chunrong

Abstract excerpt

Heart failure is a multifaceted clinical syndrome, with obesity identified as a significant modifiable risk factor. This study employed a two-sample Mendelian randomization (MR) design, incorporating obesity data across life stages, to elucidate the causal link between obesity and heart failure. Data on heart failure from the 2023 Finngen database and genetic predictors of obesity from the IEU OpenGWAS project...

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PMID: 39316280
DOI: 10.1007/s11739-024-03772-8

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