Article

The global randomization test: A Mendelian randomization falsification test for the exclusion restriction assumption

2022-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Mendelian randomization may give biased causal estimates if the instrument affects the outcome not solely via the exposure of interest (violating the exclusion restriction assumption). We demonstrate use of a global randomization test as a falsification test for the exclusion restriction assumption. Using simulations, we explored the statistical power of the randomization test to detect an associ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bb1aaa5-8e45-50b2-9e24-1b38de31512b
DOI: 10.1101/2022.05.03.22274459

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The global randomization test: A Mendelian randomization falsification test for the exclusion restriction assumptionDOI 10.1101/2022.05.03.22274459Read

Pleiotropy-robust Mendelian randomization.Semantic proximity Read

Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods.Semantic proximity Read

Genetic drug target validation using Mendelian randomizationSemantic proximity Read

A Bayesian approach to Mendelian randomization using summary statistics in the univariable and multivariable settings with correlated pleiotropySemantic proximity Read

Mendelian Randomization.Semantic proximity Read

A multivariable cis-Mendelian randomization method robust to weak instrument bias and horizontal pleiotropy bias.Semantic proximity Read

Testing the principles of Mendelian randomization: Opportunities and complications on a genomewide scaleSemantic proximity Read

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropySemantic proximity Read

Enhancing Mendelian Randomization Causal Inference through Pleiotropic Clustering in the Presence of Correlated Horizontal PleiotropySemantic proximity Read

MRBEE: A bias-corrected multivariable Mendelian randomization method.Semantic proximity Read

Model Checking via Testing for Direct Effects in Mendelian Randomization and Transcriptome-wide Association StudiesSemantic proximity Read