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Article

A data-adaptive method for investigating effect heterogeneity with high-dimensional covariates in Mendelian randomization.

BMC medical research methodology - 10 Feb 2024

Tian Haodong, Tom Brian D M, Burgess Stephen

Abstract excerpt

BACKGROUND: Mendelian randomization is a popular method for causal inference with observational data that uses genetic variants as instrumental variables. Similarly to a randomized trial, a standard Mendelian randomization analysis estimates the population-averaged effect of an exposure on an outcome. Dividing the population into subgroups can reveal effect heterogeneity to inform who would most benefit from...

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Identifiers

PMID: 38341532
DOI: 10.1186/s12874-024-02153-1
PMCID: PMC10858611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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