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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

2020-10-21

Abstract excerpt

Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s Disease (PD); however, pathways regulating LRRK2 subcellular localization, function, and turnover are not fully defined. We performed quantitative mass spectrometry-based interactome studies to identify 48 novel LRRK2 interactors, including the microtubule-associated E3 ubiquitin ligase TRIM1 ( Tri partite...

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Identifiers and source

Literature Corpus work
84ecb615-794b-5d61-a87d-cfd6c9194cff
DOI
10.1101/2020.10.21.336578
Open publication

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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicityDOI 10.1101/2020.10.21.336578
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