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Article

Integrated Multiomics Reveals Key Drivers and Immune Cell Phenotypes of Infrapopliteal Atherosclerosis and Calcification.

Annals of vascular surgery - 1 Sept 2026

Li Xiaodong, Huang Yao, Yu Yihan, Zheng Xu, Sun Xiaolei

Abstract excerpt

BACKGROUND: Infrapopliteal atherosclerosis and calcification are major causes of chronic limb ischemia. This study aimed to identify causative genes and immune cell phenotypes driving this pathology to develop targeted therapeutic strategies. METHODS: Bulk RNA transcriptomics (bulk RNA-seq) and summary data-based Mendelian randomization (SMR) were integrated to identify key genes associated with infrapopliteal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42176975
DOI: 10.1016/j.avsg.2026.05.073

Genes

CD24
CD27
MRPL18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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