Article
Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2021
Iqbal Farwah, Lupieri Adrien, Aikawa Masanori, Aikawa Elena
Abstract excerpt
The transition of healthy arteries and cardiac valves into dense, cell-rich, calcified, and fibrotic tissues is driven by a complex interplay of both cellular and molecular mechanisms. Specific cell types in these cardiovascular tissues become activated following the exposure to systemic stimuli including circulating lipoproteins or inflammatory mediators. This activation induces multiple cascades of events where...
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