Article

Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairments

2021-08-10

Abstract excerpt

<title>Abstract</title> <p>Alzheimer's disease (AD) is the prevalent cause of dementia in the ageing world population. Apolipoprotein E4 (ApoE4) allele is the key genetic risk factor for AD, although the mechanisms linking APOE4 with neurocognitive impairments and aberrant metabolism remains to be fully characterised. We discovered significantly increase in the ApoE4 contents of serum exosomes in old healthy subj...

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Literature Corpus work: 920841b4-c067-5e7d-91fe-bf33797269de
DOI: 10.21203/rs.3.rs-757423/v1

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Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairmentsDOI 10.21203/rs.3.rs-757423/v1Read

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