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A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease

20 May 2022

Abstract excerpt

Alzheimer's disease (AD) is one of the major worldwide causes of dementia that is characterized by irreversible decline in learning, memory loss, and behavioral impairments. Mitophagy is selective autophagy through the clearance of aberrant mitochondria, specifically for degradation to maintain energy generation and neuronal and synaptic function in the brain. Accumulating evidence shows that defective mitophagy...

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PMID: 35669462
DOI: 10.3389/fnagi.2022.881239

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