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Article

A Review of APOE Genotype-Dependent Autophagic Flux Regulation in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Chen Huiyi, Chen Feng, Zhang Miaoping, Chen Yanting, Cui Lili, Liang Chunmei

Abstract excerpt

Autophagy is a basic physiological process maintaining cell renewal, the degradation of dysfunctional organelles, and the clearance of abnormal proteins and has recently been identified as a main mechanism underlying the onset and progression of Alzheimer's disease (AD). The APOE ɛ4 genotype is the strongest genetic determinant of AD pathogenesis and initiates autophagic flux at different times. This review...

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PMID: 34569952
DOI: 10.3233/JAD-210602

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