Article

Overexpression of Cathepsin S Exacerbates Lupus Pathogenesis Through TLR7 and IFN-α in Transgenic Mice

2021-02-11

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless...

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Literature Corpus work: 91fa0758-fc20-578d-9b7c-a1bdeb87de4c
DOI: 10.21203/rs.3.rs-181707/v1

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