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Article

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Autophagy - 1 Jan 2015

Weindel Chi G, Richey Lauren J, Bolland Silvia, Mehta Abhiruchi J, Kearney John F, Huber Brigitte T

Abstract excerpt

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, defined by loss of B cell self-tolerance that results in production of antinuclear antibodies (ANA) and chronic inflammation. While the initiating events in lupus development are not well defined, overexpression of the RNA-recognizing toll-like receptor (TLR)7 has been linked to SLE in humans and mice. We postulated that autophagy plays an...

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Source

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Identifiers

PMID: 26120731
DOI: 10.1080/15548627.2015.1052206
PMCID: PMC4590645

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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