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Article

Yaa autoimmune phenotypes are conferred by overexpression of TLR7.

European journal of immunology - 1 Jul 2008

Fairhurst Anna-Marie, Hwang Sun-hee, Wang Andrew, Tian Xiang-Hong, Boudreaux Christopher, Zhou Xin J, Casco Jose, Li Quan-Zhen, Connolly John E, Wakeland Edward K

Abstract excerpt

The Y-linked autoimmune accelerating (Yaa) locus drives the transition to fatal lupus nephritis when combined with B6.Sle1 in our C57BL/6J (B6)-congenic model of systemic autoimmunity. We and others recently demonstrated that the translocation of a cluster of X-linked genes onto the Y chromosome is the genetic lesion underlying Yaa (Subramanian, S. et al., Proc. Natl. Acad. Sci. USA 2006. 103: 9970-9975;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18521959
DOI: 10.1002/eji.200838138
PMCID: PMC2993003

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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