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Article

sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway.

Journal of immunology research - 1 Jan 2023

Bao Yatao, Lian Meng, Chen Yong, Gu Xiaotian, Cao Kunyu, Du Xiaoping, Ju Jiyu

Abstract excerpt

Genetic factors play an important role in the pathogenesis of systemic lupus erythematosus (SLE), and abnormal Toll-like receptor (TLR) signaling pathways are closely related to the onset of SLE. In previous studies, we found that the mutant somatic nuclear autoantigenic sperm protein (sNASP) gene in the mouse lupus susceptibility locus Sle2 can promote the development of lupus model mice, but the mechanism is...

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Identifiers

PMID: 37771504
DOI: 10.1155/2023/4877700
PMCID: PMC10533267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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