Article

Inhibition of Sting rescues lupus disease by the regulation of Lyn-mediated dendritic cell differentiation

2019-10-21

Abstract excerpt

SLE (systemic lupus erythematosus) is an autoimmune disease that causes chronic inflammation and leads to fatality if left untreated. Immune complex-mediated inflammation and type I IFN signaling pathways are one of the mechanisms initiating lupus disease. Signaling through stimulator of interferon genes (STING) leads to the production of type I IFN and inflammatory cytokines. However, the role of STING in lupus m...

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Literature Corpus work: 642fa14a-3ca4-5b02-b9c2-32334de0861a
DOI: 10.1101/810192

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