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Article

Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunity

12 Aug 2025

Abstract excerpt

Toll like receptor (TLR) 7 and 9, endosomal sensors for RNA and DNA, are key mediators of autoreactivity. Although generally considered homologous, they paradoxically have opposing effects on lupus: TLR7 exacerbates the disease while TLR9 protects from it How they mediate opposing effects in autoimmunity remains undetermined. We hypothesized that differences in signaling qualities of the Toll-Interleukin 1...

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PMID: 40794441
DOI: 10.1172/jci189566

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