Article

sNASP mutation aggravates to the TLR4-mediated inflammation in SLE by TAK1 pathway

2023-06-01

Abstract excerpt

Genetic factors play an important role in the pathogenesis of systemic lupus erythematosus, and abnormal TLR signaling pathways are closely related to the onset of SLE. In previous studies, we found that the mutant somatic nuclear autoantigenic sperm protein (sNASP) gene in the mouse lupus susceptibility locus Sle2 can promote the development of lupus model mice, but the mechanism is still unclear. Here, we stimul...

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Literature Corpus work: 7c82ce88-c427-5d5e-8cd3-c020b2c3e824
DOI: 10.22541/au.168558854.42179764/v1

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