Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2012

Hwang Sun-Hee, Lee Huiyin, Yamamoto Miwako, Jones Leigh A, Dayalan Jivanaah, Hopkins Richard, Zhou Xin J, Yarovinsky Felix, Connolly John E, Curotto de Lafaille Maria A, Wakeland Edward K, Fairhurst Anna-Marie

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of antinuclear autoantibodies. Antinuclear autoantibody development is recognized as one of the initial stages of disease that often results in systemic inflammation, kidney disease, and death. The etiology is complex, but it is clear that innate pathways may play an important role in disease progression....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to B-Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Lupus Erythematosus, Systemic

Share to Mice, 129 Strain

Share to Multiprotein Complexes

Share to Toll-Like Receptor 7

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23150717
DOI: 10.4049/jimmunol.1202195
PMCID: PMC3544945

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.PMID 23150717Read ↗

B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice.Semantic proximity Read ↗

Opposing Impact of B Cell–Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic InflammationSemantic proximity Read ↗

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.Semantic proximity Read ↗

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of LupusSemantic proximity Read ↗

B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.Semantic proximity Read ↗

Monogenic autoimmunity caused by TLR7 gain-of-functionSemantic proximity Read ↗

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of LupusSemantic proximity Read ↗

Sustained NPSLE-like phenotype in the absence of systemic lupus-like disease in TLR7-deficient B6.Nba2 mice.Semantic proximity Read ↗

Yaa autoimmune phenotypes are conferred by overexpression of TLR7.Semantic proximity Read ↗

Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunitySemantic proximity Read ↗

Human and Murine Toll-like Receptor-Driven Disease in Systemic Lupus Erythematosus.Semantic proximity Read ↗

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus ErythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.