Article
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.
Nature communications - 17 Jun 2015
Aspalter Irene Maria, Gordon Emma, Dubrac Alexandre, Ragab Anan, Narloch Jarek, Vizán Pedro, Geudens Ilse, Collins Russell Thomas, Franco Claudio Areias, Abrahams Cristina Luna, Thurston Gavin, Fruttiger Marcus, Rosewell Ian, Eichmann Anne, Gerhardt Holger
Abstract excerpt
Sprouting angiogenesis drives blood vessel growth in healthy and diseased tissues. Vegf and Dll4/Notch signalling cooperate in a negative feedback loop that specifies endothelial tip and stalk cells to ensure adequate vessel branching and function. Current concepts posit that endothelial cells default to the tip-cell phenotype when Notch is inactive. Here we identify instead that the stalk-cell phenotype needs to...
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