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Article

VEGF and Notch in tip and stalk cell selection.

Cold Spring Harbor perspectives in medicine - 1 Jan 2013

Blanco Raquel, Gerhardt Holger

Abstract excerpt

Sprouting angiogenesis is a dynamic process in which endothelial cells collectively migrate, shape new lumenized tubes, make new connections, and remodel the nascent network into a hierarchically branched and functionally perfused vascular bed. Endothelial cells in the nascent sprout adopt two distinct cellular phenotypes--known as tip and stalk cells--with specialized functions and gene expression patterns. VEGF...

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Topics

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Share to Cell Movement
Share to Endothelial Cells
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Membrane Proteins

Share to Neovascularization, Physiologic

Share to Receptors, Notch

Share to Vascular Endothelial Growth Factor A

Source

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Identifiers

PMID: 23085847
DOI: 10.1101/cshperspect.a006569
PMCID: PMC3530037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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