Article

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesis

2025-08-01

Abstract excerpt

The VEGF ligand and its main receptor VEGFR2 are considered to be essential for endothelial differentiation, proliferation, sprouting and survival. Blood vessels cannot form in growing embryos or tissues when VEGF/VEGFR2 signalling is compromised in all cells. The Anti-VEGF blocking antibody is one of the most widely used antibodies in the clinics, blocking angiogenesis in cancer, wound healing or in ischemic dise...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 648315f2-caba-5fd6-b93f-f9e8edead591
DOI: 10.1101/2025.07.31.667893

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesisDOI 10.1101/2025.07.31.667893Read

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance.Semantic proximity Read

Vascular heterogeneity: VEGF receptors make blood vessels specialSemantic proximity Read

Endothelial cells require functional FLVCR1a during developmental and adult angiogenesisSemantic proximity Read

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.Semantic proximity Read

von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish.Semantic proximity Read

A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular LesionsSemantic proximity Read

<i>Crk/Crkl</i> regulates early angiogenesis in mouse embryos by accelerating endothelial cell maturationSemantic proximity Read

Low dose AKT inhibitor miransertib cures PI3K-related vascular malformations in preclinical models of human diseaseSemantic proximity Read

Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice.Semantic proximity Read

Regulation of Vegf signaling by natural and synthetic ligands.Semantic proximity Read

Vasculogenesis and Angiogenesis in VEGF Receptor-1 Deficient Mice.Semantic proximity Read

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene.Semantic proximity Read