Article
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.
Development (Cambridge, England) - 1 Apr 2013
Villefranc Jacques A, Nicoli Stefania, Bentley Katie, Jeltsch Michael, Zarkada Georgia, Moore John C, Gerhardt Holger, Alitalo Kari, Lawson Nathan D
Abstract excerpt
Vascular endothelial growth factor C (Vegfc) is a secreted protein that guides lymphatic development in vertebrate embryos. However, its role during developmental angiogenesis is not well characterized. Here, we identify a mutation in zebrafish vegfc that severely affects lymphatic development and leads to angiogenesis defects on sensitized genetic backgrounds. The um18 mutation prematurely truncated Vegfc,...
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