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Article

Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway.

Cell systems - 16 Jul 2025

Lee Sung Hoon, Kang Tae-Yun, Shang Xingbo, Levchenko Andre

Abstract excerpt

Responses of endothelial cells to elevated levels of vascular endothelial growth factor (VEGF), frequently accompanying local decrease in oxygen supply, include loosening of cell contacts, rearrangement of cells in vessel remodeling, and ultimately, angiogenic growth. How these complex processes, occurring on diverse time scales, are coordinated and how they are guided by a single key signaling input is still...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40541183
DOI: 10.1016/j.cels.2025.101321
PMCID: PMC12276906

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