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Article

Endothelial Notch signalling limits angiogenesis via control of artery formation.

Nature cell biology - 1 Aug 2017

Hasan Sana S, Tsaryk Roman, Lange Martin, Wisniewski Laura, Moore John C, Lawson Nathan D, Wojciechowska Karolina, Schnittler Hans, Siekmann Arndt F

Abstract excerpt

Angiogenic sprouting needs to be tightly controlled. It has been suggested that the Notch ligand dll4 expressed in leading tip cells restricts angiogenesis by activating Notch signalling in trailing stalk cells. Here, we show using live imaging in zebrafish that activation of Notch signalling is rather required in tip cells. Notch activation initially triggers expression of the chemokine receptor cxcr4a. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Microscopy, Video

Share to Neovascularization, Physiologic

Share to Receptor, Notch1

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Source

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Identifiers

PMID: 28714969
DOI: 10.1038/ncb3574
PMCID: PMC5534340

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