Article
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.
Nature cell biology - 1 Aug 2017
Pitulescu Mara E, Schmidt Inga, Giaimo Benedetto Daniele, Antoine Tobiah, Berkenfeld Frank, Ferrante Francesca, Park Hongryeol, Ehling Manuel, Biljes Daniel, Rocha Susana F, Langen Urs H, Stehling Martin, Nagasawa Takashi, Ferrara Napoleone, Borggrefe Tilman, Adams Ralf H
Abstract excerpt
Endothelial sprouting and proliferation are tightly coordinated processes mediating the formation of new blood vessels during physiological and pathological angiogenesis. Endothelial tip cells lead sprouts and are thought to suppress tip-like behaviour in adjacent stalk endothelial cells by activating Notch. Here, we show with genetic experiments in postnatal mice that the level of active Notch signalling is more...
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