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Article

Flt-1 (VEGFR-1) coordinates discrete stages of blood vessel formation.

Cardiovascular research - 1 Jul 2016

Chappell John C, Cluceru Julia G, Nesmith Jessica E, Mouillesseaux Kevin P, Bradley Vanessa B, Hartland Caitlin M, Hashambhoy-Ramsay Yasmin L, Walpole Joseph, Peirce Shayn M, Mac Gabhann Feilim, Bautch Victoria L

Abstract excerpt

AIMS: In developing blood vessel networks, the overall level of vessel branching often correlates with angiogenic sprout initiations, but in some pathological situations, increased sprout initiations paradoxically lead to reduced vessel branching and impaired vascular function. We examine the hypothesis that defects in the discrete stages of angiogenesis can uniquely contribute to vessel branching outcomes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27142980
DOI: 10.1093/cvr/cvw091
PMCID: PMC4909163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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