Article

Structural insights into the viral proteins binding by TRIM7 reveal a general C-terminal glutamine recognition mechanism

2022-03-24

Abstract excerpt

The E3 ligase TRIM7 has emerged as a critical player in viral infection and pathogenesis. A recent study found that TRIM7 inhibits human enteroviruses through ubiquitination and proteasomal degradation of viral 2BC protein by targeting the 2C moiety of 2BC protein. Here, we report the crystal structures of TRIM7 in complex with 2C, where the C-terminal region of 2C is inserted into a positively charged groove of t...

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Literature Corpus work: 91cec866-43a8-5156-b928-ca061cae63dc
DOI: 10.1101/2022.03.24.485560

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Structural insights into the viral proteins binding by TRIM7 reveal a general C-terminal glutamine recognition mechanismDOI 10.1101/2022.03.24.485560Read

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