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Article

Inhibition of coronaviral exonuclease activity by TRIM-mediated SUMOylation

2025-07-29

Abstract excerpt

<h4>SUMMARY</h4> Members of the TRIM E3 ligase family are effectors of the host innate or intrinsic defense against various viruses; however, how specific TRIM proteins antagonize coronavirus infection is still largely elusive. Through an RNAi screen targeting 71 human TRIM genes, we identified multiple TRIM proteins with antiviral or proviral activity against SARS-CoV-2. TRIM32 potently restricted SARS-CoV-2 rep...

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Identifiers and source

Literature Corpus work
5fecba73-33b8-51f4-a899-59ef97fa74b2
DOI
10.1101/2025.07.28.667286
Open publication

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Inhibition of coronaviral exonuclease activity by TRIM-mediated SUMOylationDOI 10.1101/2025.07.28.667286
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