TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication.

doi:10.1038/s41467-024-54762-5

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Article

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication.

Nature communications - 30 Nov 2024

Gonzalez-Orozco Maria, Tseng Hsiang-Chi, Hage Adam, Xia Hongjie, Behera Padmanava, Afreen Kazi, Peñaflor-Tellez Yoatzin, Giraldo Maria I, Huante Matthew, Puebla-Clark Lucinda, van Tol Sarah, Odle Abby, Crown Matthew, Teruel Natalia, Shelite Thomas R, Moreno-Contreras Joaquin, Terasaki Kaori, Makino Shinji, Menachery Vineet, Endsley Mark, Endsley Janice J, Najmanovich Rafael J, Bashton Matthew, Stephens Robin, Shi Pei-Yong, Xie Xuping, Freiberg Alexander N, Rajsbaum Ricardo

Abstract excerpt

SARS-CoV-2 is a highly transmissible virus that causes COVID-19 disease. Mechanisms of viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in tissue damage. Here we show that the host E3-ubiquitin ligase TRIM7 acts as an inhibitor of apoptosis and SARS-CoV-2 replication via ubiquitination of the viral membrane (M) protein. Trim7-/- mice exhibit increased pathology and virus...

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Identifiers

PMID: 39616206
DOI: 10.1038/s41467-024-54762-5
PMCID: PMC11608229

Genes

TRIM7

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