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The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

2023-09-27

Abstract excerpt

<h4>ABSTRACT</h4> The transporter associated with antigen processing (TAP) is a key player in the MHC class I-restricted antigen presentation and an attractive target for immune evasion by viruses. Bovine herpesvirus 1 (BoHV-1) impairs TAP-dependent antigenic peptide transport through a two-pronged mechanism in which binding of the UL49.5 gene product to TAP both inhibits peptide transport and promotes its protea...

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Literature Corpus work
c536b06b-e8f2-531b-b31b-1dabaf3a48dd
DOI
10.1101/2023.09.27.559663
Open publication

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The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradationDOI 10.1101/2023.09.27.559663
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