Article

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

2024-12-05

Abstract excerpt

SARS-CoV-2 infection poses a major threat to public health, and understanding the mechanism of viral replication and virion release would help identify therapeutic targets and effective drugs for combating the virus. Herein, we identified E3 ubiquitin-protein ligase Itchy homolog (ITCH) as a central regulator of SARS-CoV-2 at multiple steps and processes. ITCH enhances the ubiquitination of viral envelope and memb...

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Identifiers and source

Literature Corpus work: b3777b5d-3346-5700-a8f1-236dbfefbeb4
DOI: 10.1101/2024.12.04.624804

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