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TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

2024-06-17

Abstract excerpt

SARS-CoV-2 is a highly transmissible virus that causes COVID-19 disease. Mechanisms of viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in tissue damage. We identified the host E3-ubiquitin ligase TRIM7 as an inhibitor of apoptosis and SARS-CoV-2 replication via ubiquitination of the viral membrane (M) protein. Trim7 -/- mice exhibited increased pathology and virus titers...

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Literature Corpus work
f7a3c840-e20f-5eeb-bfbc-9e0cc9c850c5
DOI
10.1101/2024.06.17.599107
Open publication

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TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replicationDOI 10.1101/2024.06.17.599107
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