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The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

1 Oct 2021

Abstract excerpt

Viral proteins localize within subcellular compartments to subvert host machinery and promote pathogenesis. To study SARS-CoV-2 biology, we generated an atlas of 2422 human proteins vicinal to 17 SARS-CoV-2 viral proteins using proximity proteomics. This identified viral proteins at specific intracellular locations, such as association of accessary proteins with intracellular membranes, and projected SARS-CoV-2...

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Influenza Virus Research Studies
interferon and immune responses
SARS-CoV-2 and COVID-19 Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34597346
DOI: 10.1371/journal.ppat.1009412

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