Article

Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

2023-07-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> B cells drive the production of autoreactive antibody-secreting cells (ASCs) in autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Sjögren’s syndrome, causing long-term organ damage. Current treatments for antibody-mediated autoimmune diseases target B cells or broadly suppress the immune system. However, pre-existing long-lived ASCs are often refractory to t...

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Literature Corpus work: 91c8ed1b-69cc-5b43-b6d3-5fd2ef4fd8f1
DOI: 10.1101/2023.07.27.550912

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