Article
Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins.
International journal of molecular sciences - 24 Jul 2018
Trezise Stephanie, Karnowski Alexander, Fedele Pasquale L, Mithraprabhu Sridurga, Liao Yang, D'Costa Kathy, Kueh Andrew J, Hardy Matthew P, Owczarek Catherine M, Herold Marco J, Spencer Andrew, Shi Wei, Willis Simon N, Nutt Stephen L, Corcoran Lynn M
Abstract excerpt
Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity, however, deregulated or excessive antibody production contributes to the pathology of autoimmune diseases, while transformation of ASCs results in the malignancy Multiple Myeloma (MM). Despite substantial recent improvements in treating these conditions, there is as yet no widely used ASC-specific therapeutic approach, highlighting a...
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