Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recent Advances in Lupus B Cell Biology: PI3K, IFNγ, and Chromatin

14 Jan 2021

Abstract excerpt

In the autoimmune disease Systemic Lupus Erythematosus (SLE), autoantibodies are formed that promote inflammation and tissue damage. There has been significant interest in understanding the B cell derangements involved in SLE pathogenesis. The past few years have been particularly fruitful in three domains: the role of PI3K signaling in loss of B cell tolerance, the role of IFNγ signaling in the development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to PI3K/AKT/mTOR signaling in cancer
Share to Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33519824
DOI: 10.3389/fimmu.2020.615673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recent Advances in Lupus B Cell Biology: PI3K, IFNγ, and ChromatinPMID 33519824Read ↗

Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.Semantic proximity Read ↗

Abnormalities of the type I interferon signaling pathway in lupus autoimmunity.Semantic proximity Read ↗

IFN‐γ Mediates the Development of Systemic Lupus ErythematosusSemantic proximity Read ↗

Regulation of B-cell function by miRNAs impacting Systemic lupus erythematosus progressionSemantic proximity Read ↗

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiationSemantic proximity Read ↗

Uncovering Immune Surveillance Deficiency in B Cell-Driven Autoimmune DiseaseSemantic proximity Read ↗

Abnormalities of T cell signaling in systemic lupus erythematosusSemantic proximity Read ↗

IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodiesSemantic proximity Read ↗

Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosusSemantic proximity Read ↗

Immunopathogenesis of systemic lupus erythematosus: An update.Semantic proximity Read ↗

Variant-to-function mapping in lupus links <i>IL12A</i> to the expansion of disease-associated B cells with a cytotoxic programSemantic proximity Read ↗

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.