Article

ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis

2024-02-19

Abstract excerpt

<h4>ABSTRACT</h4> Systemic Lupus Erythematosus (SLE) is an autoimmune disease, the pathophysiology and genetic basis of which are incompletely understood. Using a forward genetic screen in multiplex families with systemic lupus erythematosus (SLE) we identified an association between SLE and compound heterozygous deleterious variants in the non-receptor tyrosine kinases (NRTKs) ACK1 and BRK. Experimental blockade...

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Literature Corpus work: c77de7c7-52f8-50c7-9b14-8e44d5855127
DOI: 10.1101/2024.02.15.24302255

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