Article

Macrophage-instructed GSDME couples glioblastoma cell-state plasticity with inflammatory cell death

2026-07-23

Abstract excerpt

Glioblastoma (GBM) cell states reflect spatial microenvironmental interactions. Here, using COMET spatial proteomics and RNAscope across multiregional human GBM tissue, spanning tumor cores with pseudopalisading regions, infiltrative margins and peripheral regions, together with multiplex spatial profiling of 202 specimens from 33 patients with matched primary and recurrent tumors, we identify full-length gasdermi...

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Identifiers and source

Literature Corpus work: 91bc6dd2-3789-5486-acbd-0e1c5f7f1e18
DOI: 10.64898/2026.07.22.740157

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