Back to search

Article

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

2024-05-17

Abstract excerpt

Glioblastoma (GBM) is the most prevalent and aggressive primary brain malignancy in adults. Nevertheless, the cellular heterogeneity and complexity within the GBM microenvironment (TME) are still not fully understood, posing a significant obstacle in the advancement of more efficient immunotherapies for GBM. In this study, we conducted an integrated analysis of 48 tumor fragments from 24 GBM patients at the single...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6acce415-9882-5c80-81be-9ce04c2aa679
DOI
10.1101/2024.05.15.594316
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaDOI 10.1101/2024.05.15.594316
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in GlioblastomaSemantic proximity
Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity
Molecular Heterogeneity and Immunosuppressive Microenvironment in GlioblastomaSemantic proximity
Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated MacrophageSemantic proximity
Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages.Semantic proximity
Molecular biology of the deadliest cancer – glioblastoma: what do we know?Semantic proximity
Distinct tumor-TAM interactions in IDH-stratified glioma microenvironments unveiled by single-cell and spatial transcriptomicsSemantic proximity
Immune Microenvironment in Glioblastoma Subtypes.Semantic proximity
Distinct Tumor-TAM Interactions in IDH-Stratified Glioma Microenvironments unveiled by Single-Cell and Spatial TranscriptomicsSemantic proximity
Single-Cell Omics in Dissecting Immune Microenvironment of Malignant Gliomas—Challenges and PerspectivesSemantic proximity
Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of GliomasSemantic proximity
Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomasSemantic proximity
Select a neighboring publication to make it the new centre.