Article

Single-cell and spatial transcriptomic profiling of primary versus recurrent glioblastoma identifies PLOD2 as a core orchestrator of hypoxic niche remodeling and mesenchymal transition

2026-07-07

Abstract excerpt

<title>Abstract</title> <p> Glioblastoma (GBM) recurrence features acquired treatment resistance and tumor microenvironment (TME) remodeling, yet conserved drivers remain elusive due to inter-cohort heterogeneity. To identify core mechanisms, we integrated multiple large-scale single-cell/single-nucleus datasets, high-resolution 6000-plex CosMx spatial transcriptomics, and an 890-sample bulk cohort, complemented...

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Literature Corpus work: 9f8b8299-1f0b-580a-8c08-779a8a203b73
DOI: 10.21203/rs.3.rs-10158987/v1

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