Article

Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions

2025-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Treatment resistance in glioblastoma (GBM) is largely driven by the extensive multi-level heterogeneity that typifies this disease. Despite significant progress toward elucidating GBM’s genomic and transcriptional heterogeneity, a critical knowledge gap remains in defining this heterogeneity at the spatial level. To address this, we employed spatial transcriptomics to map the architecture of the...

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Literature Corpus work: 72ded65a-adb1-5469-a923-c8c2ab4ccd4a
DOI: 10.1101/2025.04.04.647096

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