Article

A Single-Cell and Spatial Atlas of MVP-PAN Evolution Reveals a Desmoplastic Dependency to Overcome Glioblastoma Resistance

2025-12-29

Abstract excerpt

Therapeutic resistance in IDH-wildtype glioblastoma (GBM) is driven by an intricate interplay between cellular plasticity and protective microenvironmental niches. By constructing the GRIT-Atlas—a massive transcriptomic compendium encompassing nearly one million high-quality single cells across 17 cohorts—and cross-analyzing it with 48 independent Visium spatial transcriptomics sections, we discover a recurrent “S...

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Literature Corpus work: 30700f91-8ed9-5cff-90a6-923884e4fd16
DOI: 10.64898/2025.12.25.696471

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