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Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastoma

15 Apr 2025

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is a highly lethal malignant intracranial tumor, distinguished from low-grade glioma by histopathological hallmarks such as pseudopalisading cells around necrosis (PAN) and microvascular proliferation (MVP). To date the spatial organization of the molecular and cellular components of these specific histopathological features has not been fully elucidated. METHODS: Here, using bulk...

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PMID: 40234880
DOI: 10.1186/s12967-025-06185-z

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